Ariella Glasner researched two types of immune cells in cancers during her studies: an innate lymphocyte known as a natural killer cell (NK), because it eradicates tumors and virally infected cells, and a suppressor regulatory T-cell (Treg), which plays a major role in shaping the development of various cancers. Treg cells‘ canonic function is the suppression of immune responses, but they also participate in tissue repair and regeneration. Dr. Glasner observed these cells in various biological contexts, focusing first on basic mechanisms that regulate activity, then zooming in on their roles in the tumor microenvironment (TME). The lab aims to comprehensively map the entire spectrum of interactions between immunocytes and the TME, which plays a crucial role in supporting the tumor, by identifying negative and positive tumor regulator programs, studying localization mediated effects, and mapping the genetic and epigenetic mediators that take part in the immune-TME interplay.